Neil Andrew D. Bascos, Ph.D.

Associate Professor

PROFILE

Program Director, Protein Proteomics Metabolomics Facility, Philippine Genome Center (2020 – Present)

Member, CHED Technical Panel on Biology and Molecular Biology

PhD Molecular and Cellular Biology, Tulane University, LA USA

BS Molecular Biology and Biotechnology, University of the Philippines, Diliman, Philippines 

CONTACT

PUBLICATIONS

LABORATORY

Protein Structure and Immunology Laboratory

At PSI Lab, we study how proteins perform their functions using structure-based approaches . Our studies utilize biophysical techniques, such as nuclear magnetic resonance (NMR), X-ray crystallography, and circular dichroism (CD) spectroscopy. Biochemical assays such as the enzyme-linked immunosorbent assay (ELISA) are also used in immunological studies. We also do protein modeling to analyze the potential effects of mutations and variations on protein function. PSI Lab has existing collaborations with establishments such as the UP Diliman NMR Facility, the Protein, Proteomics, and Metabolomics Facility (PPMF) of the Philippine Genome Center (PGC), and the National Synchrotron Radiation Research Center in Hsinchu, Taiwan. 

‚ÄúScientia Per Structuram‚ÄĚ

Research Area

Characterization of the molecular mechanisms underlying sex-specific immune responses against infections and protein antigens. 

Elucidation and characterization of the proteins involved in the immune and stress responses of tardigrades

Study of integrin subunit structure and their role in modulating SARS-CoV2 infection

Proteomic Profiling of Philippine Sardinella Species (S. tawilis and S. hualiensis) 

Proteomic Analysis of Philippine SARS-CoV2 Patient Plasma using Artificial Intelligence and High Resolution Mass Spectrometry 

Selected Publications

Abesamis, K. I. A., Bagoyo, C. S., & Bascos, N. A. D. (2021). Investigating the Effect of a Non-Conservative Mutation (G273D) on Integrin Alpha6-Beta4 Binding Interactions. Biophysical Journal, 120(3), 267a.

Lazaro, J. E. H., Bascos, N. A. D., Tablizo, F. A., Abes, N. S., Paynaganan, R. I. D., Miguel, M. A., … & Center, P. G. (2019). Genome-wide analysis for variants in Philippine Trypanosoma evansi isolates with varying drug resistance profiles. Philippine Journal of Science, 148(S1), 219-233.

Bascos, N. A. D., Emralino, F. L. C., Liu, F. C., Concepcion, C. P., Altamia, M., Huang, Y. C., … & Palmes-Saloma, C. (2018). Biophysical and Functional Characterization of asFP504, a Novel Fluorescent Protein from the Philippines. Philippine Journal of Science, 147(1), 65-74.

Bascos NAD, Mayer MP, Bukau B, Landry SJ. The Hsp40 J-domain modulates Hsp70 conformation and ATPase activity with a semi-elliptical spring. Protein Sci. 2017 Sep;26(9):1838-1851. doi: 10.1002/pro.3223. Epub 2017 Jul 17. PMID: 28685898; PMCID: PMC5563141.