Director, UP System Technology Transfer and Business Development Office (2010 – 2014)
Key Account Manager, London Biotechnology Network
Senior Scientist, Cancer Research UK Beatson Institute
Postdoctoral Research Associate, University College London, UK
Postdoctoral Fellow, Case Western Reserve University School of Medicine, OH USA
Postdoctoral Fellow, University of Otago Medical School, New Zealand
MPhil Bioscience Enterprise, University of Cambridge, UK
PhD Biochemistry and Molecular Biology, Australian National University, Australia
BS Biology, University of the Philippines, Diliman, Philippines
Strategic Planning Panel (SPP) Lead for the Philippines, ASEAN Diagnostics (Dx) Initiative
The Disease Molecular Biology and Epigenetics Laboratory (DMBEL) was founded in 2011. The laboratory’s main interests are the functional characterization of novel non-hotspot mutations in oncogenes and tumor suppressors, as well as the regulatory roles of lncRNAs, microRNAs and circRNAs in cancer pathogenesis. The laboratory is also part of a nationwide drug discovery consortium and runs a laboratory services arm.
The laboratory offers students opportunities to acquire basic and advanced laboratory skills in molecular and cellular biology — from gene manipulation, RT-qPCR/quantigene assays, reporter and cell-based assays, through to immunocytochemistry, fluorescence and time-lapse microscopy, flow cytometry and high-content imaging. Projects are funded by the DOST/PCHRD, OVCRD and the NIMBB.
Garrido, J.A.M.G.; Alcantara, K.M.M.; Danac, J.M.C.; Serrano, F.E.C.; Cutiongco-de la Paz, E.M.; Garcia, R.L. The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene. Cells 2021, 10, 3423. doi:10.3390/cells10123423
Cruz CRV, Ferrer JLM and Garcia RL. Concomitant and decoupled effects of cigarette smoke and SCAL1 upregulation on oncogenic phenotypes and ROS detoxification in lung adenocarcinoma cells. Scientific Reports (2021) 11:18345. https://rdcu.be/cxOnK
Danac J.M.C. and Garcia R.L. CircPVT1 attenuates negative regulation of NRAS by let-7 and drives cancer cells towards oncogenicity. Scientific Reports (2021) 11:9021. https://rdcu.be/cjvnt
Danac JM, Uy AG and Garcia RL. Exosomal microRNAs in colorectal cancer: Overcoming barriers of the metastatic cascade (Review). Int J Mol Med 47: 112, 2021. doi:10.3892/ijmm.2021.4945