National Institute of Molecular Biology and Biotechnology
University of the Philippines, Diliman

National Institute of Molecular Biology and Biotechnology

Denise Noelle M. Bascos, Ph.D.

Associate Professor

PROFILE

Deputy Director for Academic Affairs, National Institute of Molecular Biology and Biotechnology (2012 – 2016)

PhD Molecular and Cellular Biology, Tulane University, LA USA

MS Molecular Biology and Biotechnology, University of the Philippines, Diliman, Philippines

BS Molecular Biology and Biotechnology, University of the Philippines, Diliman, Philippines 

CONTACT

PUBLICATIONS

LABORATORY

  • Protein Structure and Immunology Laboratory

Protein Structure and Immunology Laboratory

At PSI Lab, we study how proteins perform their functions using structure-based approaches . Our studies utilize biophysical techniques, such as nuclear magnetic resonance (NMR), X-ray crystallography, and circular dichroism (CD) spectroscopy. Biochemical assays such as the enzyme-linked immunosorbent assay (ELISA) are also used in immunological studies. We also do protein modeling to analyze the potential effects of mutations and variations on protein function. PSI Lab has existing collaborations with establishments such as the UP Diliman NMR Facility, the Protein, Proteomics, and Metabolomics Facility (PPMF) of the Philippine Genome Center (PGC), and the National Synchrotron Radiation Research Center in Hsinchu, Taiwan. 

“Scientia Per Structuram”

Research Area

Characterization of the molecular mechanisms underlying sex-specific immune responses against infections and protein antigens. 

Elucidation and characterization of the proteins involved in the immune and stress responses of tardigrades

Study of integrin subunit structure and their role in modulating SARS-CoV2 infection

Proteomic Profiling of Philippine Sardinella Species (S. tawilis and S. hualiensis) 

Proteomic Analysis of Philippine SARS-CoV2 Patient Plasma using Artificial Intelligence and High Resolution Mass Spectrometry 

Selected Publications

Bascos NA, Mirano-Bascos D, Saloma CP. Structural analysis of spike protein mutations in the sars-cov-2 p. 3 variant. bioRxiv. 2021 Jan 1. doi: 10.1101/2021.03.06.434059.

Mapalo MA, Arakawa K, Baker CM, Persson DK, Mirano-Bascos D, Giribet G. The Unique Antimicrobial Recognition and Signaling Pathways in Tardigrades with a Comparison Across Ecdysozoa. G3 (Bethesda). 2020 Mar 5;10(3):1137-1148. doi: 10.1534/g3.119.400734. Erratum in: G3 (Bethesda). 2020 Jun 1;10(6):2127. PMID: 31969428; PMCID: PMC7056985.

Itang, L. A., Stec, D., Mapalo, M. A., Mirano-Bascos, D., & Michalczyk, Ł. (2020). An integrative description of Mesobiotus dilimanensis, a new tardigrade species from the Philippines (Eutardigrada: Macrobiotidae: furciger group). Raffles Bulletin of Zoology. 2020; 68. doi: 10.26107/RBZ-2020-0003.

Mapalo MA, Stec D, Mirano-Bascos D, Michalczyk Ł. Mesobiotus philippinicus sp. nov., the first limnoterrestrial tardigrade from the Philippines. Zootaxa. 2016 Jun 20;4126(3):411-26. doi: 10.11646/zootaxa.4126.3.6. PMID: 27395596.