Pia B. Bagamasbad, PhD
Established in 2015, the Molecular Endocrinology Laboratory is devoted to studying the role of hormones in the development of the nervous system and hormone-dependent cancers.
The laboratory uses mouse and human cultured cells as a model system, along with advanced molecular biology assays including reverse transcriptase quantitative PCR, chromatin immunoprecipitation, chromosome conformation capture, lentiviral transduction and next generation sequencing, to investigate the molecular mechanisms of hormone action at the transcriptional level.
Identification of lncRNAs regulated by thyroid hormones and glucocorticoids in neuronal cells through RNA sequencing and in silico data mining.
Drug screen for selective androgen receptor modulators for prostate cancer therapy.
Investigation of the synergistic interactions between glucocorticoids and thyroid hormone on transcriptional regulation and its functional consequence in neuronal development.
Elucidation of the mechanism behind the glucocorticoid therapy paradox in breast cancer.