PSI Lab logo The Protein Structure and Immunology Laboratory (PSI Lab) utilizes structural analysis of proteins to study cellular and immunological systems.

Ongoing Projects
Study of integrin subunit structure and their role in the modulation of cancer metastasis

Prediction of epitope immunodominance and the rational design of vaccines using a combination of structural biology and computational techniques.

Studies are performed through biophysical techniques. These include nuclear magnetic resonance (NMR), X-ray crystallography, and circular dichroism spectroscopy. Biochemical assays such as the enzyme-linked immunosorbent assay are also used in the immunological studies.

PSI Lab currently houses a four-node computing grid. This system is used for protein structure modelling and other computationally intensive algorithms. In order to perform experiments requiring high value equipment, PSI Lab has existing collaborations with establishments such as the UP Diliman NMR Facility and the National Synchrotron Radiation Research Center in Hsinchu, Taiwan.

 

PRINCIPAL INVESTIGATORS:
Denise Noelle M. Bascos, PhD
Neil Andrew D. Bascos, PhDDMB&NDB

Research Publications Bascos, N. (2015). Molecular docking: A practical approach for protein interaction analysis. Biotechnology and bioinformatics: advances and applications for bioenergy, bioremediation, and biopharmaceutical research (pp. 345-354).

Bascos, N. A. D., & Landry, S. J. (2015). Structural Rigidity Regulates Functional Interactions in the Hsp40-Hsp70 Molecular Machine. BIOPHYSICAL JOURNAL, 108(2), 210a. Biophysical Society.

Jose, G., Villamil, G., Katrina, K., Cantos, M., Nacu, L., Bascos, A., & Mirano-Bascos, D. (2013). Computational Analysis of Integrin Subunit Glycosylation: Investigations on its Role in Orienting Ligand-Receptor Interaction. 57th Annual Meeting of the Biophysical-Society (Vol. 104, p. 509a-510a). Biophysical Society.

Mirano-Bascos, D., Tongol-rivera, P., Villacorte, E. A., & Escueta, A. D. (2013). Characterization of the Population Demographics and the MSP-1 Block 2 Allele Gene Frequencies of P . falciparum Infected Individuals in Davao , Philippines. Tropical Medicine and Health, 41(1), 1-6.

Mirano-Bascos, D., Steede, N. K., Robinson, J. E., & Landry, S. J. (2010). Influence of disulfide-stabilized structure on the specificity of helper T-cell and antibody responses to HIV envelope glycoprotein gp120. Journal of virology, 84(7), 3303-11. doi:10.1128/JVI.02242-09