PRINCIPAL INVESTIGATOR:
Reynaldo L. Garcia, PhD

The Disease Molecular Biology and Epigenetics Laboratory (DMBEL) was founded in 2011. The laboratory’s main interests are the functional characterization of novel non-hotspot mutations in oncogenes and tumor suppressors, as well as the regulatory roles of lncRNAs and microRNAs in cancer pathogenesis.

The laboratory is also part of a nationwide drug discovery consortium, and has more recent interests in X-linked Dystonia Parkinsonism.

The laboratory offers students opportunities to acquire basic and advanced laboratory skills in molecular and cellular biology, from gene manipulation to cell-based assays, through to immunocytochemistry and high-content imaging. Projects are funded by the DOST/PCHRD, OVCRD and the NIMBB.

Current Projects

Functional characterization of novel mutations in downstream effectors of the EGFR signaling pathway among Filipino colorectal cancer patients

In vitro bioactivities and toxicities of extracts, drug candidates and dosage forms

Confirmatory and orthogonal assays to eliminate artefactual drug bioactivities: Expanded suite of assays to include multiple hallmarks of cancer

Investigations on the molecular pathogenesis of X-linked dystonia Parkinsonism

Tumor-Released Exosomes – Mutational status and differential sorting of RNA cargo

Cigarette smoke-induced regulation of the IncRNA LUCAT1 and its functional sequelae